Contact: Spencer Gibson Head of Cell Biology, Research Institute in Oncology and Hematology Professor (tenured), Departments of Biochemistry and Medical Genetics and Immunology University of Manitoba phone: 204-787-2051 Email: Dr Spencer Gibson Ph D In maintaining integrity and homeostasis of multicellular organisms, the balance between cell death and survival is fundamentally important.
When this balance is altered, diseases occur such as cancer.
This paradox of BNIP3 killing cancer cells and being over expressed in live cells within tumours is a focus of our research.
To date three explanations could account of these differences.
One protein important in the regulation of cell death is the Bcl-2 BH-3 only member BNIP3.
BNIP3 expression is induced under low oxygen (hypoxia) conditions and is over expressed in solid tumours in hypoxic regions.
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